Date: Wed, 26 Nov 2003 17:20:25 -0500
Subject: Antibiotics - Critical Thinking
Bill:
Today I wanted to take one of my poly-trauma patients off antibiotics 48 hours after ORIF of an open humerus. The orthopedist told me that the patient had to be on antibiotics "until the drains came out". I challenged this belief as being totally unsupported by any evidence, and suggested that if he felt strongly about it we should subject the practice to prospective study. He replied that he couldn't ever study the problem ethically because of the risk to "his" patient.
Well, isn't that special ! After all, the use of drains at all in bone surgeries is of dubious value at best if you believe the 2001 Cochrane Group meta-analysis (Cochrane Database Syst Rev. 2001;(4):CD001825.)
Also, a MEDLINES search of "fractures / drains / antibiotics" yields (you guessed it) zero relevant hits. Adding "prospective / randomized " yielded zero hits, period. So frankly, I remain to be convinced that "covering the drains" is not just one more ruse used by surgical subspecialists who are antibiotic "believers" (ie orthopods, CV surgeons, neurosurgeons etc.) to prolong prophyllactic antibiotic use despite 1) the abundant evidence that it doesn't work, 2) the P&T committee, 3) the CDC and 4) the protests of the critical care specialists who have to treat the whole patient, including their multi-drug resistant pneumonias.
So post this on your ortho websites: I'm looking for some critical-thinking orthopedists who are willing to subject these unproven beliefs about the antibiotic "coverage" of wound drains to a prospective study. This should be a multicenter trial done under the aegis of the Surgical Infection Society. Come on all you budding orthopedic academics, don't you see that this is a NEJM paper??
CJH
Carl Hauser
UMDNJ
PS. - The antibiotic demanded was Ancef - the wound culture was MRSE
PPS - I bet I get zero hits from this, too!
From: Norman E. McSwain
Date: Wed, 26 Nov 2003 16:38:59 -0600
Actually drains are the problem - No drains=no need for antibiotics
See how that flies
Norman McSwain, MD, FACS
Tulane University School of Medicine
Charity Hospital Trauma Center
NASA
Date: Wed, 26 Nov 2003 18:34:58 -0500
From: carl hauser
Right Norm:
The problem here is the the assumption that orthopedic hardware requires 'coverage'. Now I'm not sure whether orthopedic hardware is Gram (+) or Gram (-), but I do agree that it needs coverage - with healthy, well perfused tissue.
The principle here is no different than a piece of mesh in a hernia or PTFE in a vessel. In fact stainless steel is probably less infectable than most surgical implants. Anyway, it's not the steel that gets infected, it's the nutritious dead stuff that we create in a wound that bacteria thrive on. The FB simply makes it harder to clear infections that we cause with imperfect technique. Unfortunately though, many surgical specialties that don't focus on the modern, rational use of anti-infectives as part of their knowledge base still truly rely on the ancient traditions of 'Listerism' and truly believe that the bacterial innoculum is all that matters. For crying out loud - I had a spine surgeon ask to put one of our patients on Ancef the other day to "cover" the Gardner-Wells tongs. If that's not insanity then I don't know what is. Last, drains and antibiotics are often just crutches for surgeons who either can't or won't obtain ideal wound conditions.
But that doesn't mean drains and antibiotics don't have valid uses. They do - we just need to know what they are.
CJH
Date: Thu, 27 Nov 2003 00:13:30 -0500
From: Bill Burman
Carl
See OTA Basic Fracture Course lecture by John Esterhai:
I have concerns that the belief system pertaining to antibiotic use may be based on one of those old time religions which featured drug festivals and human sacrifice.
In New York state all health care practictioners have recently received a CD-ROM called the "SASNY Information Toolkit" from a state funded coalition of major health plans and medical professional groups called "Save Antibiotic Strength New York" (http://www.sasny.org/). A snippet from the intro reads:
"The germ-killing power of antibiotics has saved many lives, but the overuse of antibiotics has created a growing public health problem. Deadly bacteria are becoming increasingly resistant to these very same antibiotics. The World Health Organization estimates that nearly two Americans an hour die from antibiotic resistant infections. Inappropriate and overuse of antibiotics has lead to this problem."
Since this appears to be more deadly and costly than our investment in Iraq, there is more than a moral imperative to study the matter. The study of antibiotic duration after open fractures has been on the OTA multi-center "to-do" list for sometime now.
I'll cross-post your prompt to the OTA list.
Bill Burman, MD
HWB Foundation
Date: Thu, 27 Nov 2003 08:18:52 -0600
From: Obremskey, William T
Great idea. You could put together a protocol and post on this web-site for all interested to give feed back or begin IRB process. A potential problem is given relatively low infection rate even w/ open fxs of 3-7%.(OTA Open Fx immediate vs delayed closure and SPRINT studies preliminary data indicate it in this range) One would need 1000-2000 patients to show no difference in null hypothesis. (I have not run any stats for Power Analysis, but this is a guess). This is doable, but would need several sites.
Best data for drains and fractures is out of Charlotte:
Lang GJ. Richardson M. Bosse MJ. Greene K. Meyer RA Jr. Sims SH. Kellam JF. Efficacy of surgical wound drainage in orthopaedic trauma patients: a randomized prospective trial. [Clinical Trial. Journal Article. Randomized Controlled Trial] Journal of Orthopaedic Trauma. 12(5):348-50, 1998 Jun-Jul.
OBJECTIVE: To study the efficacy of closed suction drainage in clean nonemergent surgical fracture fixation or bone grafting on the extremities or pelvis. DESIGN: A prospective randomized trial.
SETTING: The orthopaedic trauma service of a Level I trauma hospital.
PATIENTS: Patients were older than age eighteen years and undergoing clean nonemergent surgical fracture fixation or bone grafting procedures on the extremities (excluding hands and feet) or pelvis.
INTERVENTION: The application of a surgical drain.
MAIN OUTCOME MEASUREMENTS: Wound drainage, edema, hematoma and erythema, dehiscence, infection, and need for surgery or readmission were followed for six weeks. A univariate analysis with Student's t test for continuous variables and chi-squared analysis for all categorical data were used, with a p value of < or = 0.05 considered statistically significant.
RESULTS: A total of 202 patients were randomized to 102 patients with no drain and 100 patients with a drain. There was no significant difference between the groups with regard to injury severity, systemic disease, age, body weight, physical status, or estimated blood loss. There was no significant difference between the drain and no-drain groups in any of the parameters evaluated.
CONCLUSION: There is no significant difference between drained and nondrained wounds in clean, nonurgent orthopaedic trauma surgery. It appears that drainage systems can be safely eliminated in this group.
This study was probably under powered for the null hypothesis, but best data I know of in literature. It does not address open fxs.
The OTA sponsored Immediate vs Delayed Closure of open fxs protocol requires only 24 hrs of antibiotics after wound closure w/ or w/o drain.
Good idea and could be good study w/ support from General Trauma Surgeons and Ortho trauma surgeons.
Bill